We’ve assembled this list of the top 10 US-based companies by revenue, focusing on how they’re seeking to leverage AI and generative AI in their businesses. These use cases span both internal operational and external customer-facing initiatives. AI “agents” are emerging as a theme — but they aren’t as dominant as you might expect given the hype around that topic. Most commonly mentioned use cases are focused on optimization and efficiency across existing workflows. That trend is followed very closely by using AI to deliver more personalized customer interactions.
The list of companies includes legacy industrial entities and conglomerates founded in the last century (e.g. Exxon Mobil and Berkshire Hathaway), along with the digital dominators of this one, like Alphabet, Amazon, and Apple. Heavily represented are pharmaceuticals and healthcare players like McKesson and CVS Health.
The summaries below were all sourced entirely from public and investor-facing corporate docs, including Form 10-K filings and corporate press releases, as well as from industry-specific trade publications.
1. Walmart
2023 Revenue: $648 billion
Walmart is leveraging AI to enhance its retail operations and customer experience. Its GenAI-powered search function already provides personalized, conversational shopping assistance across their e-commerce properties, while inline AI tools deliver tailored product recommendations, gift ideas, and content suggestions based on customer preferences. On the backend, an AI-driven inventory management system optimizes stock levels, predicts demand, and adapts to regional buying habits. They have also used their scale to develop and train their own retail-specific Large Language Models (LLMs) under the “Wallaby” moniker, which taps into their vast data troves to deliver new kinds of information to employees and customers. Finally, worth noting is Walmart’s explicit “Responsible AI Pledge,” emphasizing transparency, privacy, fairness, and accountability in its use of this emerging technology.
2. Amazon
2023 Revenue: $575 billion
The e-commerce king has been leveraging AI and ML everywhere since their firm introduced the “users who bought this also bought…” feature way back in the dot-com era. With their new LLM-powered “Amazon Bedrock” enabling users to develop and deploy GenAI driven apps at will, they will benefit from the trillions of agentic API calls running through their infrastructure. On the operations side, “Amazon Q” is their home-built agent that can summarize customer interactions, generate insights, and augment business decisions in real-time. On the front of the house, they are embedding GenAI across all segments. For example, they launched a tool called “Rufus” to assist customers with purchase decisions. With subsidiaries like Audible and Twitch, they plan to power content creation with GenAI. Think automated audiobook production, for instance.
3. Apple
2023 Revenue: $391 billion
Not surprisingly, this is the company that is most coy about what it’s doing behind the scenes with artificial intelligence. It was only a few months ago that the world heard for the first time what industry insiders had been speculating on — the arrival of Apple’s homegrown LLMs and the various customer applications it would spawn. Now we know it is a thing, and it is branded Apple Intelligence or “AI.” Points to the marketing team for that one. We also now know, in alignment with their brand, that they have chosen to build smaller LLMs that run on devices, such as iPhones, in order to keep user data as safe as possible. The only time user data leaves the device, it stays within Apple’s encrypted infrastructure which they label “Private Cloud Compute.” (Apple had pie on its face earlier in 2025 when Apple Intelligence began cooking up false news alerts, and it quickly disabled the feature.)
4. United Health Group
2023 Revenue: $372 billion
Minnesota-based United Health Group (UHG) operates two primary business platforms: UnitedHealthcare, which is their insurance and managed care offering, and Optum which is the services, technology, and analytics division. Examples of their adoption and planned forward use of GenAI include virtual assistants, such as their AVA program, which uses conversational AI in patient interactions for more tailored care. OptumIQ centralizes patient data using classic NLP and machine learning for predictive analytics around conditions like diabetes and Alzheimer’s. On the backend, GenAI makes it easier to query databases and is helping automate claims management, plus workflow automation in their pharmacy benefits business. Being in a highly-regulated industry like healthcare, not surprisingly, many of their public statements have a cautionary tone. Their 10-K filingss are peppered with phrases like “uncertainty of US and international regulations concerning health data and AI/ML technologies” and “escalating cyber threats, heightened by AI/ML advances.” Like Walmart, they are keenly aware of potential downside from irresponsible use of AI.
5. Berkshire Hathaway
2023 Revenue: $265 billion
Berkshire is an industrial conglomerate with 22 business units across industries such as insurance, energy, rail, manufacturing, autos, retail, and food services. So lots of potential places to apply AI. GEICO has implemented AI for claims processing efficiency and fraud detection. They partnered with Tractable AI to leverage computer vision and deep learning to assess vehicle damage with human-like accuracy. BNSF Railway is using AI on wheel inspections, employing thermal sensors and machine vision to monitor the health of over 1.5 million wheels in motion, processing over 35 million daily readings to predict maintenance needs. Lubrizol, a chemicals manufacturer, is integrating AI into its beauty / cosmetics R&D strategy, using AI for clinical testing, data analysis, and developing new ingredients.
6. CVS Health
2023 Revenue: $357 billion
Headquartered in Woonsocket, Rhode Island, CVS Health Corporation has many divisions which include CVS Pharmacy; pharmacy benefit arm Caremark; CVS Specialty, which caters to chronic conditions; MinuteClinic, its retail healthcare offering; and of course Aetna, the insurance giant that it acquired in 2018. CVS Pharmacy is automating workflows for pharmacists to accelerate prescription verification and (here’s that word again) “personalize” patient experience. The Health Engagement Engine leverages proprietary clinical algorithms and cloud-native technologies to connect enterprise functions, enabling cost management and health improvement. Finally, Aetna is working to automate 30 percent of its customers’ prior authorizations requests. Like Walmart and United Health, in their public statements, they are committing to safe AI practices, for health equity, data privacy, and to minimize clinician burnout.
7. Exxon Mobil
2023 Revenue: $334 billion
As one of the largest global energy companies, Exxon Mobil is composed of divisions and business units made up of “upstream” (discovery, exploration and extraction) activities and various downstream processing and chemicals divisions plus product solutions units producing fuels, lubricants, plastics and the like. The main cited uses of AI and GenAI are upstream seismic data analysis to enhance exploration and production, and they project they will leverage GenAI to save $15 billion in operating costs by 2027 through workflow optimizations in their Global Business Services unit, for end-to-end processes like procurement, supply chain, logistics, and so on. Finally, to support their carbon targets, AI is helping them design and implement smarter carbon capture technologies.
8. Alphabet
2023 Revenue: $307 billion
If Apple is the shy, demure kid at the high school dance, Alphabet is the one taking center stage on the dance floor and enjoying the spotlight. Clearly, if any one company’s future hangs on LLMs and GenAI, it’s Google’s. Their latest 10-K filing is full of their AI/GenAI products and strategies. This is 15 of more than 25 remarks about AI from that document.
- Google Search understands user intent with models like BERT.
- Google Translate supports translation across 133 languages.
- Google Photos uses AI for organization, searching, and editing.
- Google Cloud offers AI-optimized infrastructure, platforms, and assistive agents.
- DeepMind’s AlphaFold advances vaccines, drug discovery, and enzyme development.
- Flood forecasting models provide real-time warnings and information.
- Gemini, their multimodal AI model, integrates text, code, audio, images, and video.
- Vertex AI enables developers to build and deploy generative AI applications.
- Duet AI in Cloud assists developers with coding and software management.
- Duet AI in Workspace enhances workflows, organization, and meetings.
- Bard offers experimental AI for collaboration, coding, and app integration.
- Dream Screen in YouTube generates AI-created video and image backgrounds.
- AI in Search and Shopping Ads powers conversational experiences and insights.
- Pixel phones integrate on-device AI for photo and audio enhancements.
- AI is central to cybersecurity, protecting against and responding to threats.
9. McKesson
2023 Revenue: $232 billion
As the largest pharma and medical-surgical solutions provider in the US this Irving, Texas-based entity is influential and seems to be pursuing AI strategy via a series of partnerships — a “buy” rather than “build” approach. For example, McKesson’s subsidiary Ontada partnered with Microsoft in October of last year on a cancer research initiative that leveraged AI to analyze 150 million unstructured oncology documents. (Here’s a short video about this.) Ontada’s EMR system used AI to reduce data processing times from six months to weeks.
McKesson also implemented AI in its pharma distribution centers using KNAPP’s Pick-it-Easy Robot for pharmaceutical order processing. During their Q4 FY24 earnings call, McKesson briefly mentioned early-stage investments in AI tools and algorithms to enhance supply chain operations. For customer service, McKesson partnered with a company called Five9’s to build an “intelligent virtual assistant” with GenAI, essentially a chatbot. Finally, the company extended a partnership with Genpact to integrate AI into its finance operations.
10. Cencora
2023 Revenue: $294 billion
Rounding out our list is a healthcare company focused on drug development services and disease prevention. Formerly called AmerisourceBergen and based in Conshohocken, Pennsylvania, Cencora employs over 46,000 individuals across two primary divisions: US Healthcare Solutions and International Healthcare Solutions. US-based subsidiaries include AmerisourceBergen Drug Corporation (ADBC), ASD Specialty Healthcare, Besse Medical, and a veterinary play with VetSource, their animal health solutions offering. Much like its peer McKesson, Cencora partners with tech companies and consultants to experiment with and deliver GenAI solutions. For example, they tapped the Accenture/Salesforce solution called LifeSciencesCloud to modernize patient engagements. They partnered with Infinitus.ai in 2024 to develop and deploy an AI agent that resolves customer insurance verification requests ten times faster than manual processes.
Another Cencora AI initiative focused on improving patient adherence to their prescription plans, according to this case study, was a “25 percent reduction in specific nurse call interventions…enabling reallocation of nurse time to other needed interventions.”
